Quantum-Si’s Innovative Protein Barcoding Enhances Next-Gen Screening for mRNA Therapeutics

Summary

Nucleic acid-based therapeutics, including antisense oligonucleotides (ASO), small interfering RNA (siRNA), messenger RNA (mRNA), immunomodulatory DNA/RNA, and gene-editing guide RNA (gRNA), are promising because they can treat diseases by targeting their genetic information directly in vivo. These treatments can provide long-lasting or even curative effects by inhibiting, adding, replacing, or editing genes.

This technical note introduces an innovative approach utilizing the protein barcoding application on the Quantum-Si Platinum® Pro Next-Generation Protein Sequencer.™ This method enhances and accelerates mRNA-LNP in vitro and in vivo screening by providing a cost-effective, scalable, multiplexed solution with single-molecule resolution. It addresses inefficiencies in existing workflows and allows for deeper insights into proteomics.

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