Protein Barcodes for Next-Generation Protein Sequencing™

Summary

Discover the power of protein barcoding with Quantum-Si’s Next-Generation Protein Sequencing™ on the Platinum® instrument. This innovative technology combines the accessibility of DNA-based methods with the versatility of protein barcoding. By attaching peptides to macromolecular linkers and employing dye-labeled recognizers and aminopeptidases, researchers can generate distinct kinetic signatures for each peptide, enabling high-confidence sequence alignment. Explore our application note for criteria on peptide barcode design, library generation methods, and practical examples of how peptide barcodes revolutionize protein screening, including a 300-fold enrichment in nanobody abundance after positive selection using protein barcodes.

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